Tips and Tricks

1. Get familiar with Just Enough Items.  The default keys to to show recipes (R) and show uses (U) for blocks and items integrates with all the included mods, and shows you how to make something or how to use it.  Some items can only be obtained by mob drops, but some can be created!  For example, you can obtain Blizz Powder by killing the Blizz mob, but they can be hard to locate.  Instead, you can place snowballs in a Fluid Transposer and pipe Destablized RedStone onto it to make Blizz Powder.  Use the @"mod name" search string to see all the items/blocks from that mod only.
2. Make a jetpack.  They are invaluable for navigating the Nether, reaching floating Slime Islands, and just getting away from enemies.  Craft some Slime Boots to wear while you are using your jetpack to negate all fall damage, and use the bounces to get around even more quickly that you would otherwise be able to with the lower tier jetpacks.
3. Build a Smeltery as soon as you can.  Start doubling all your ores, especially rarer ones like Gold.  You can also save some iron by casting gears in the Smeltery instead of crafting them.  Trust me, you'll need lots of iron for AE2, ExtremeReactors and Draconic Evolution.  Put Cobblestone in the Smeltery to make more blocks to expand the capacity of the Smeltery.  Place multiple Drains and Faucets going to multiple Basins and tables, to cast multiple pieces or blocks at a time.
4. Save Platinum in raw ore form until you have machines that can process it to double output.  Iridium doesn't spawn anywhere in the world, but can be created by processing Platinum the right way...
5. Build a Reactor.  Even a basic 3x3x3 reactor can output a decent amount of power early game, and can be scaled up over time to mid-late game use.  Use the Big Reactors simulator to play around with designs, or build my favorite design: a 7x7x7 (5x5x5 inside) Gelid Cryotheum-cooled reactor with 5 columns of fuel rods in a plus design.  Once you convert this to an actively cooled reactor be sure to use Super Laminated Fluiducts to input water and output steam.  A companion 7x7x7 (5x5x5 inside) Turbine will only use 25% of the steam generated, so set the fuel rods appropriately.  One 7x7x7 Reactor will support four 7x7x7 Turbines.
6. Build an animal farm and slaughterhouse.  You may also need to make an automated plant farm of some kind for breeding materials.  Industrial Foregoing has all the machines you'll need.  Save enough pink slime to fill a bucket, but wait until you have a Mob Imprisonment Tool to capture the Pink Slime mob that spawn when you dump the bucket in the world.
• Build a mob spawning room.  You can rely on vanilla mechanics, or use a Drop of Evil dropped from a Wither Skeleton to curse the grass and make Cursed Earth, which greatly increases spawning mechanics.  Use a Mob Crusher to kill and grab items and Essence, then pipe the essence into a Mob Duplicator.
• Gotta Catch Em All!  Try and capture at least one of every Mob, to throw into your spawner room as needed.  Throw your Pink Slime mob into the Mob Duplicator and watch it rain pink Slime drops.
7. Make a multi-block kitchen with Cooking For Blockheads.  Certain foods don't keep you very full, and leave you needing to eat again soon.  Variety is the spice of life!  Or just bypass eating altogether and make yourself a Meat Feeder, then use it on a container with Liquid Meat.  Put that Mob Slaughter Factory to use!   As long as you keep that item in your inventory, you'll automatically eat from it as needed.